I-High-purity shark chondroitin sulfate iyisithako esiyinhloko sokunakekelwa kwezempilo okuhlangene
I-Chondroitin sulfate (CS) iyi-glycosaminoglycan ebalulekile exhunyaniswe ngokuhlanganyela namaprotheni ukuze akhe ama-proteoglycans.Isakazwa kabanzi ku-matrix ye-extracellular kanye ne-cell surface yezicubu zezilwane, futhi iyingxenye ebalulekile yezicubu ezixhumene nezilwane, ezitholakala ngobuningi ku-cartilage.Isakhiwo esiyisisekelo se-chondroitin sulfate sakhiwe ngokushintshana kwe-D-glucuronic acid ne-N-acetylgalactosamine ngamabhondi e-glycosidic, aphinde axhunywe engxenyeni ewumgogodla weprotheni ukuze kwakheke isakhiwo se-proteoglycan esiyinkimbinkimbi.
I-chondroitin sulfate etholakala kushaka ingenye yazo, okuyi-acidic mucopolysaccharide substance elungiswe ngezicubu ze-shark cartilage.Kubonakala njengempushana emhlophe noma emhlophe, engenaphunga, ukunambitheka okungathathi hlangothi.I-Chondroitin shark sulfate ingenye yezingxenye eziyinhloko zezicubu ezixhumene nezilwane ezincelisayo, futhi itholakala kabanzi ku-cartilage, amathambo, imisipha, imigqa, i-sarcolemma, nezindonga zemithambo yegazi.
Isebenza njengokugcinwa nokusekelwa ku-articular cartilage.Ukudla okulinganiselwe kwe-chondroitin sulfate kungasiza ukugcina izicubu ze-cartilage, ukunciphisa ukuvuvukala nobuhlungu, ukuthuthukisa ukungasebenzi kahle kwamalunga, nokuphepha okuphezulu.Ivame ukusetshenziswa kanye ne-glucosamine, inhlanganisela ethuthukisa kakhulu emtholampilo ubuhlungu obumaphakathi kuya kobunzima be-osteoarthritis futhi ivuse i-collagen entsha ne-proteoglycans kuma-chondrocyte.
| Igama Lomkhiqizo | Ushaka Chondroitin Sulfate Soidum |
| Umsuka | Umsuka Woshaka |
| Izinga Lekhwalithi | I-USP40 Standard |
| Ukubukeka | Impushana emhlophe iye emhlophe |
| Inombolo ye-CAS | 9082-07-9 |
| Inqubo yokukhiqiza | inqubo ye-enzymatic hydrolysis |
| Okuqukethwe Kwamaprotheni | ≥ 90% nge-CPC |
| Ukulahlekelwa Ekumisweni | ≤10% |
| Okuqukethwe Kwamaprotheni | ≤6.0% |
| Umsebenzi | Ukusekelwa Kwezempilo Okuhlangene, I-Cartilage kanye Nempilo Yamathambo |
| Isicelo | Izithako zokudla Kuthebhulethi, Amaphilisi, noma Impushana |
| Isitifiketi se-Halal | Yebo, I-Halal Iqinisekisiwe |
| Isimo se-GMP | I-NSF-GMP |
| Isitifiketi Sezempilo | Yebo, isitifiketi Sezempilo siyatholakala ngenjongo yokugunyazwa ngokwezifiso |
| I-Shelf Life | Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza |
| Ukupakisha | 25KG/Isigubhu, Ukupakisha Kwangaphakathi: Izikhwama Ze-PE Ephindwe Kabili, Ukupakisha Kwangaphandle: Isigubhu Sephepha |
| INTO | INKCAZO | INDLELA YOKUHLOLA |
| Ukubukeka | Impushana emhlophe ecwebezelayo | Okubonakalayo |
| Ukuhlonza | Isampula iqinisekisa ngelabhulali yereferensi | Nge-NIR Spectrometer |
| I-spectrum yokumuncwa kwe-infrared yesampula kufanele ibonise ubukhulu kuphela kumaza wamaza afanayo naleyo ye-chondroitin sulfate sodium WS. | Nge-FTIR Spectrometer | |
| Ukwakheka kwama-disaccharides: Isilinganiso sempendulo ephezulu ku-△DI-4S kuya ku-△DI-6S ayikho ngaphansi kuka-1.0 | I-HPLC ye-Enzymatic | |
| I-Optical Rotation: Hlangana nezimfuneko zokuzungezisa ukubona, ukuzungezisa okuthile ekuhlolweni okuthile | I-USP781S | |
| I-Assay(Odb) | 90%-105% | I-HPLC |
| Ukulahlekelwa Ekumisweni | < 12% | I-USP731 |
| Amaprotheni | <6% | USP |
| Ph (1%H2o Isixazululo) | 4.0-7.0 | I-USP791 |
| Ukuzungezisa okuqondile | - 20°~ -30° | I-USP781S |
| I-Residue On Ingition (Isisekelo Esomile) | 20%-30% | I-USP281 |
| I-Organic Volatile Residual | I-NMT0.5% | I-USP467 |
| I-sulfate | ≤0.24% | I-USP221 |
| I-Chloride | ≤0.5% | I-USP221 |
| Ukucaca (5%H2o Isixazululo) | <0.35@420nm | I-USP38 |
| Electrophoretic Purity | I-NMT2.0% | I-USP726 |
| Umkhawulo wama-disaccharides athile | ＜10% | I-HPLC ye-Enzymatic |
| Izinsimbi Ezisindayo | ≤10 PPM | I-ICP-MS |
| Inani Lepuleti Eliphelele | ≤1000cfu/g | I-USP2021 |
| Imvubelo & Isikhunta | ≤100cfu/g | I-USP2021 |
| I-Salmonella | Ukungabikho | I-USP2022 |
| E.Coli | Ukungabikho | I-USP2022 |
| I-Staphylococcus Aureus | Ukungabikho | I-USP2022 |
| Usayizi Wezinhlayiyana | Kwenziwe ngokwezifiso ngokuya ngezidingo zakho | Endlini |
| Ukuminyana kwenqwaba | >0.55g/ml | Endlini |
Okokuqala, i-chondroitin sulfate iyi-glycosaminoglycan etholakala kabanzi kumatrix e-extracellular yezicubu.Ethanjeni, itholakala ikakhulukazi ku-periphery of chondrocytes futhi iyingxenye ebalulekile ye-cartilage extracellular matrix.I-substance isiza uqwanga ukuthi luthole amanzi nezakhamzimba, ngaleyo ndlela lugcine uqwanga lumanzi futhi lunwebeka, futhi lusize ekugcineni ukusebenza okuvamile kwamalunga.
Okwesibili, umphumela we-physiological we-chondroitin sulfate ubaluleke kakhulu ku-cartilage ye-articular.Ingakwazi ukubopha ama-molecule amanzi, ihogele ama-molecule amanzi abe ama-proteoglycan, iqinise uqwanga futhi yandise inani le-synovial fluid emgodini ohlangene, igcobe futhi isekele ukujoyina.Ngale ndlela, ukuhlanganyela kunganciphisa ukungqubuzana nomthelela lapho uhamba, ukuze ukuhlanganyela kuhambe ngokukhululeka.
Okokugcina, i-chondroitin sulfate iphinde isebenze ebunjiniyela bamathambo.Abacwaningi balungiselele ama-hydrogel ahlanganisiwe asekelwe ku-chondroitin sulfate, ebopha ngokuzenzakalelayo i-ion ye-inorganic futhi ikhuthaze i-bone biomineralization, ngaleyo ndlela ithuthukise amandla okuvuselela amathambo.Lokhu kunezinhlelo zokusebenza ezibalulekile zokuhlinzwa kwamathambo emtholampilo njengokulungisa ukukhubazeka kwethambo kanye nokuxhunyelelwa kwethambo.
1. Thuthukisa impilo ehlangene: I-Chondroitin sulfate ingenye yezingxenye eziyinhloko ze-articular cartilage, ezingasiza i-articular cartilage ukuze igcine ukuqina kwayo namanzi, futhi ngaleyo ndlela igcine umsebenzi ojwayelekile wokuhlangana.Ngokufaka i-chondroitin sulfate, ingakhuthaza ukulungiswa nokuvuselelwa kwe-articular cartilage, ngaleyo ndlela kubambezele inqubo yokuwohloka kwamalunga.
2. Yehlisa ubuhlungu obuhlangene: i-chondroitin sulfate inganciphisa impendulo yokuvuvukala ekuhlanganyeleni, inciphise ukugqugquzelwa kwe-synovium ehlangene, bese inciphisa ubuhlungu obuhlangene.Lokhu kunomphumela obalulekile wokudambisa izinhlungu ezigulini ezinezifo ezihlangene njenge-arthritis.
3. Thuthukisa ukuhamba okuhlangene: I-Chondroitin sulfate ithuthukisa ukuhamba nokuguquguquka kwesihlanganisi ngokwandisa ukugcoba okuhlangene nokunciphisa ukungqubuzana okuhlangene.Lokhu kwenza ukuhlangana kube bushelelezi ngesikhathi sokunyakaza, kunciphisa ukuphazamiseka okubangelwa ukuqina kwamalunga noma ukunyakaza okulinganiselwe.
4. Vikela i-articular cartilage: I-Chondroitin sulfate ingavimbela ukuwohloka kwe-articular cartilage, futhi ikhuthaze ukuhlanganiswa nokukhishwa kwe-chondrocytes, ukuze ibambe iqhaza ekuvikeleni i-articular cartilage.Lokhu kusiza ukubambezela inqubo yokuguga nokuwohloka kwamalunga.
1. Ukuphulukiswa kwesilonda nokulungiswa kwesikhumba: I-Chondroitin sulfate idlala indima ebalulekile enqubweni yokuphulukiswa kwesilonda.Ingakhuthaza ukuvuselelwa nokulungiswa kwezicubu zesilonda, ithuthukise ukunwebeka nokucinana kwesikhumba, futhi isize ekwehliseni ukwakheka kwezibazi.Ngakho-ke, i-chondroitin sulfate inezinhlelo zokusebenza ezingase zibe khona ezinkambisweni zokuhlinzwa, ukwelashwa kokushisa nokulungiswa kwesikhumba.
2. Imboni yezimonyo: Ngenxa yezindawo zayo ezinhle zokuthambisa kanye nomphumela wokulwa nokuguga, i-chondroitin sulfate nayo isetshenziswa kabanzi embonini yezimonyo.Ingangezwa emikhiqizweni yokunakekelwa kwesikhumba njengesithako esithambisayo, esiza ukugcina ibhalansi yomswakama wesikhumba futhi ithuthukise ukunwebeka kwesikhumba nokucwebezela.Ngaphezu kwalokho, i-chondroitin sulfate nayo ingavimbela ukukhiqizwa kwama-radicals mahhala, ibambezele inqubo yokuguga yesikhumba, futhi yenze isikhumba sibe sincane futhi sinempilo.
3. Ubunjiniyela bezicubu kanye nemithi yokuvuselela kabusha: Emkhakheni wobunjiniyela bezicubu kanye nemithi yokuvuselela, i-chondroitin sulfate isetshenziswa njengengxenye yokwakhiwa kwezinto ze-biomimetic stent.Ingahlanganiswa namanye ama-biomaterials ukwenza ama-scaffolds anezakhiwo ezithile nemisebenzi yokulungisa noma ukushintshwa kwezicubu nezitho ezilimele.I-biocompatibility kanye ne-bioactivity ye-chondroitin sulfate yenza kube ikhandidethi elibalulekile emkhakheni wobunjiniyela bezicubu.
4. Umphumela we-Antitumor: Eminyakeni yamuva, ucwaningo luye lwathola ukuthi i-chondroitin sulfate nayo inamandla e-antitumor.Ingavimbela ukuqaliswa nokuqhubeka kwe-tumor ngokulawula ukukhula, ukuhlukaniswa kanye nezinqubo ze-apoptotic zamaseli wesimila.Nakuba ucwaningo olufanele lusesiteji sokuqala, ithemba lokufaka isicelo se-chondroitin sulfate emkhakheni we-anti-tumor kulindeleke.
I-Chondroitin sulfate ne-glucosamine sulfate akuzona ezezinhlobo ezifanayo.Kunomehluko ekubunjweni kwawo, ukusetshenziswa kanye nendlela yokwenza.
I-Chondroitin sulfate iyi-glycosaminoglycan enemisebenzi ehlukahlukene yezinto eziphilayo, kuhlanganise nemiphumela yokulawula i-lipid kanye ne-anti-inflammatory.Isetshenziswa kabanzi ekwelapheni i-osteoarthritis futhi iyakwazi ukunciphisa abalamuli bokuvuvukala kanye nezinqubo ze-apoptotic, kuyilapho ngesikhathi esifanayo kunciphisa ukukhiqizwa kwama-cytokines avuthayo, iNOS kanye ne-MMPs.Ngaphezu kwalokho, i-chondroitin sulfate nayo idlala indima ebalulekile ekuvikelweni nasekulungiseni i-articular cartilage, isiza i-cartilage ukuthi imelane nokucindezeleka okuqinile ngaphansi kwezimo ezihlukahlukene zokulayisha ngokwenza izicubu zimelane nokunwebeka.
Futhi i-glucosamine sulfate ingenye inhlanganisela ebalulekile, esetshenziswa ngokuyinhloko ekuvimbeleni nasekwelapheni izinhlobo ezihlukahlukene ze-osteoarthritis, njengejoyinti lamadolo kanye ne-hip joint.Isebenza ku-articular cartilage, ngokugqugquzela ama-chondrocyte ukukhiqiza ama-proteoglycans anesakhiwo esivamile se-polysome, ukuthuthukisa ikhono lokulungisa ama-chondrocyte, ukuvimbela ama-enzyme e-cartilage afana ne-collagenase ne-phospholipase A2, futhi kungavimbela ukukhiqizwa kwama-radicals mahhala angaphezulu kwe-superoxidized kumaseli awonakele, ngaleyo ndlela kubambezeleke. inqubo ye-pathological ye-osteoarthritis kanye nokuqhubeka kwesifo, ukuthuthukisa umsebenzi ohlangene, ukukhulula ubuhlungu.
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