i-collagen, uhlobo lweprotheyini yesakhiwo ku-matrix engaphandle kweseli, ibizwa ngokuthi i-Collagen, eyavela esiGrekini.I-Collagen iyiphrotheni emhlophe, e-opaque futhi engenawo amagatsha etholakala esikhunjeni, emathanjeni, ku-cartilage, amazinyo, imisipha, imisipha kanye nemithambo yegazi yezilwane.Kuyiprotheni yesakhiwo ebaluleke kakhulu yezicubu ezixhumeneyo, futhi idlala indima ekusekeleni izitho nokuvikela umzimba.I-Collagen iyiphrotheni eningi kakhulu ezilwaneni ezincelisayo, ibalwa ku-25% kuya ku-30% wawo wonke amaprotheni emzimbeni, okulingana no-6% wesisindo somzimba.
Eminyakeni yamuva nje, ngokuthuthukiswa kobuchwepheshe bokukhipha i-collagen kanye nezifundo ezijulile ngesakhiwo nezakhiwo zayo, imisebenzi yebhayoloji ye-collagen hydrolysates nama-polypeptides kancane kancane iye yaqashelwa kabanzi.Ucwaningo kanye nokusetshenziswa kwe-collagen sekuyisizinda socwaningo kwezokwelapha, ukudla, izimonyo nezinye izimboni.
Ngaphezu kwe-tryptophan ne-cysteine, i-collagen iqukethe ama-amino acid angu-18, angu-7 abalulekile ekukhuleni komuntu.I-glycine ku-collagen yenza u-30%, kanti i-proline ne-hydroxyproline ndawonye zenza cishe u-25%, okuyizinga eliphezulu kunazo zonke kuzo zonke izinhlobo zamaprotheni.Okuqukethwe kwe-alanine ne-glutamic acid nakho kuphakeme kakhulu.Ngaphezu kwalokho, iqukethe i-hydroxyproline ne-pyroglutamic acid, engavamile ukubonakala kumaprotheni avamile, kanye ne-hydroxyllysine, ecishe ingekho kwamanye amaprotheni.
I-Collagen iphrotheni yesakhiwo ku-matrix engaphandle kwamangqamuzana lapho ama-molecule ayo ehlanganiswa abe yizakhiwo ze-supramolecular.Isisindo samangqamuzana angama-300 ku.Isici esivame kakhulu sesakhiwo se-collagen isakhiwo se-helix kathathu, esiqukethe ama-alpha polypeptide amathathu ochungechungeni lwe-alpha olungakwesokunxele, ngalinye elisontekile ukuze lakhe isakhiwo se-alpha helix esisesandleni sokudla.
Isakhiwo esiyingqayizivele se-helix kathathu se-collagen senza ukwakheka kwayo kwamangqamuzana kuzinze kakhulu, futhi inokuzivikela okuphansi kwe-immunogenicity kanye ne-biocompatibility enhle.Isakhiwo sinquma indawo, futhi impahla inquma ukusetshenziswa.Ukuhlukahluka kanye yinkimbinkimbi yesakhiwo se-collagen sinquma isikhundla sayo esibalulekile emikhakheni eminingi, futhi imikhiqizo ye-collagen inethuba elihle lokufaka isicelo.
I-Collagen ingumndeni wamaprotheni.Okungenani kutholwe izakhi zofuzo ezingu-30 zamaketanga e-collagen, ezingakha izinhlobo ezingaphezu kwezingu-16 zama-molecule e-collagen.Ngokusho kokusabalalisa kwabo kanye nezici zokusebenza ku-vivo, i-collagen okwamanje ihlukaniswe i-collagen ye-interstitial, i-basal membrane collagen kanye ne-pericellular collagen.Ama-molecule e-collagen e-Interstitial ahlanganisa ingxenye enkulu ye-collagen emzimbeni wonke, okuhlanganisa uhlobo Ⅰ, Ⅱ kanye Ⅲ nama-collagen molecules, asatshalaliswa kakhulu esikhumbeni, i-tendon nezinye izicubu, phakathi kwazo uhlobo Ⅱ lwe-collagen olukhiqizwa ama-chondrocyte.I-collagen ye-basement membrane ivamise ukubizwa ngokuthi uhlobo Ⅳ collagen, esatshalaliswa kakhulu kulwelwesi olungaphansi.I-Pericellular collagen, ngokuvamile ibhala i-collagen engu-Ⅴ, ikhona ngobuningi kuzicubu ezixhumeneyo.
Ukupakisha kwethu kuwuhlobo lwe-collagen engu-25KG olufakwa esikhwameni se-PE, bese isikhwama se-PE sifakwa kusigubhu se-fiber esinelokha.Izigubhu ezingama-27 zipaletiwe kuphalethi olulodwa, futhi isiqukathi esisodwa esingamamitha angu-20 siyakwazi ukulayisha cishe izigubhu ezingu-800 ezingu-8000KG uma ziphalethiwe kanye no-10000KGS uma zingapaletiwe.
Amasampula wamahhala angaba ngu-100 amagremu ayatholakala ukuze uhlolwe uma uwacela.Sicela usithinte ukuze ucele isampula noma ikhotheshini.
Sinethimba labadayisi elichwepheshile elinikeza impendulo esheshayo nenembile emibuzweni yakho.Sithembisa ukuthi uzothola impendulo yombuzo wakho kungakapheli amahora angama-24.
Isikhathi sokuthumela: Dec-05-2022